反应详情

温度

90 °C

To 44.0 g of melted phosphorus oxybromide, 12.0 g of 2-hydroxyimidazo[1,2-a]pyridine is added at 60°-85° C. and stirred for 3 hours at 90° C. The mixture is poured into 300 ml of ice water, neutralized with aqueous ammonia and then extracted with chloroform. The collected chloroform layer is dried over anhydrous sodium sulfate. Chloroform is distilled off and the residue is purified by silica gel chromatography (eluent: chloroform) to obtain 3.5 g of the title compound as a crystalline solid.

1. extractionextracted with chloroform
2. dry with materialThe collected chloroform layer is dried over anhydrous sodium sulfate
3. distillationChloroform is distilled off
4. customthe residue is purified by silica gel chromatography (eluent: chloroform)