Chlorosuccinimide → HCID 14422465, compound

HRID 2051114Notes

Reaction equation

HRID 2051114 reaction equation
[CH2:1]([S:8][C:9]1[N:10]=[C:11]2[N:15]([CH:16]=1)[CH:14]=[CH:13][S:12]2)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Cl:17]N1C(=O)CCC1=O>ClCCl.C(Cl)(Cl)(Cl)Cl>[CH2:1]([S:8][C:9]1[N:10]=[C:11]2[N:15]([C:16]=1[Cl:17])[CH:14]=[CH:13][S:12]2)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

5

Reactant 2

HCID 31398ChlorosuccinimideHCID 14422464HCID 14422464, compound

Product 1

HCID 14422465HCID 14422465, compoundYield 87.7%

Reagents, catalysts & solvents 2

HCID 5943Carbon TetrachlorideSolventHCID 6344DichloromethaneSolvent

Procedure

6-Benzylthioimidazo[2,1-b]thiazole (2.0 g) is dissolved in a mixture of 8 ml of dichloromethane and 40 ml of carbon tetrachloride. N-Chlorosuccinimide (1.2 g) is added to the solution during 10 minutes and stirred for an hour at room temperature. The insoluble product is filtered off and the filtrate is purified by silica gel chromatography (eluent: ethylacetate) to give 2.0 g of the title compound as an oil.

Workup

  1. filtrationThe insoluble product is filtered off
  2. customthe filtrate is purified by silica gel chromatography (eluent: ethylacetate)

Sources & evidence

ORD record
ord-993f7b9485004a68b3b98b888c89ba11
Source dataset
uspto-grants-1991_05
Patent number
US05017212

Reaction notes

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