Hydrogen Peroxide → HCID 14422494, compound

HRID 2051129Notes

Reaction equation

HRID 2051129 reaction equation
[Cl:1][C:2]1[N:3]=[C:4]2[N:8]([C:9]=1[S:10]([NH2:13])(=[O:12])=[O:11])[CH2:7][CH2:6][S:5]2.[OH:14]O>C(O)(=O)C>[Cl:1][C:2]1[N:3]=[C:4]2[N:8]([C:9]=1[S:10]([NH2:13])(=[O:11])=[O:12])[CH2:7][CH2:6][S:5]2=[O:14]

Participants

4

Reactant 2

HCID 784Hydrogen PeroxideHCID 14422556HCID 14422556, compound

Product 1

HCID 14422494HCID 14422494, compoundYield 79.7%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

To a suspension of 2.0 g of 6-chloro-2,3-dihydroimidazo[2,1-b]thiazole-5-sulfonamide in 20 ml of acetic acid is add 2.2 g of 30% aqueous hydrogen peroxide, followed by stirring for 30 minutes at room temperature and further for 4 hours at 35°-45° C. Stirring is further maintained for 8 hours at room temperature, and the precipitated crystals are collected by filtration, washed with water and then dried to give 1.7 g of the title compound as colorless crystals. mp. 215°-217° C. (decomp.)

Workup

  1. stirringStirring
  2. temperatureis further maintained for 8 hours at room temperature
  3. filtrationthe precipitated crystals are collected by filtration
  4. washwashed with water
  5. customdried

Sources & evidence

ORD record
ord-e9ab8f0e33e1424d97f76ba7ecb4d4be
Source dataset
uspto-grants-1991_05
Patent number
US05017212

Reaction notes

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