1,4-Dioxane hydrochloride → Hydrochloric Acid

HRID 2051153Notes

Reaction equation

HRID 2051153 reaction equation
C(OC([NH:8][C@H:9]([C:14]([O:16][CH2:17][CH3:18])=[O:15])[CH2:10][C:11]([O-:13])=[O:12])=O)(C)(C)C.[ClH:19].O1CCOCC1>>[NH2:8][C@H:9]([C:14]([O:16][CH2:17][CH3:18])=[O:15])[CH2:10][C:11]([O-:13])=[O:12].[ClH:19]

Participants

4

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 71413625(3S)-3-[(tert-Butoxycarbonyl)amino]-4-ethoxy-4-oxobutanoate

Product 2

HCID 313Hydrochloric AcidHCID 86329063HCID 86329063, compound

Procedure

Combine the product of step A (1.14 g) with 6M HCl/dioxane (10 ml). Stir 15 minutes, decant the solution, and stir the residue with ether. Filter to obtain (S)-aspartic acid, α-ethyl ester, β-(6-chloro-7-sulfamoyl-3,4-dihydro-1,1-dioxo-1, 2,4-benzothiadiazine-3-methylamide) hydrochloride.

Workup

  1. customdecant the solution
  2. stirringstir the residue with ether
  3. filtrationFilter

Sources & evidence

ORD record
ord-9490a9b31b0140ef9bab7daef0951d62
Source dataset
uspto-grants-1991_05
Patent number
US05017567

Reaction notes

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