Pyridine → 1H-Indole-2-carboxamide

HRID 2051197Notes

Reaction equation

HRID 2051197 reaction equation
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH:3]=[C:2]1[C:10](Cl)=[O:11].[N:13]1C=CC=CC=1>C(Cl)Cl>[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH:3]=[C:2]1[C:10]([NH2:13])=[O:11]

Participants

4

Reactant 2

HCID 1049PyridineHCID 118162081H-indole-2-carbonyl Chloride

Product 1

HCID 5948321H-Indole-2-carboxamide

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Indolyl carboxylic acid amides as starting materials may be produced by reacting an indolyl carboxylic acid chloride in absolute methylene chloride with an amine in the presence of pyridine at -10° to 0°.

Workup

  1. custommay be produced
  2. customat -10° to 0°

Sources & evidence

ORD record
ord-1bb07629c5c440e796036d2c0ac6d1b6
Source dataset
uspto-grants-1991_05
Patent number
US05017582

Reaction notes

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