Water → 1-Methyl-α-[3-(trifluoromethyl)phenyl]-1H-imidazole-2-methanol

HRID 2051228Notes

Reaction equation

HRID 2051228 reaction equation
[BH4-].[Na+].[CH3:3][N:4]1[CH:8]=[CH:7][N:6]=[C:5]1[C:9]([C:11]1[CH:16]=[CH:15][CH:14]=[C:13]([C:17]([F:20])([F:19])[F:18])[CH:12]=1)=[O:10].O>CO>[CH3:3][N:4]1[CH:8]=[CH:7][N:6]=[C:5]1[CH:9]([C:11]1[CH:16]=[CH:15][CH:14]=[C:13]([C:17]([F:19])([F:18])[F:20])[CH:12]=1)[OH:10]

Participants

5

Reactant 3

HCID 962WaterHCID 4311764Sodium borohydrideHCID 5303840HCID 5303840, compound

Product 1

HCID 115361871-Methyl-α-[3-(trifluoromethyl)phenyl]-1H-imidazole-2-methanol

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

0.6 g of sodium borohydride is added to a solution of 3.6 g of 1-methyl-α-(3-trifluoromethylphenyl) -1H-imidazole-2-methanone in 25 ml of methanol. The mixture is stirred for 30 minutes and 150 ml of water are added. The precipitate obtained is filtered off and washed with water. It is recrystallized from an ethanol/water mixture.

Workup

  1. customThe precipitate obtained
  2. filtrationis filtered off
  3. washwashed with water
  4. customIt is recrystallized from an ethanol/water mixture

Sources & evidence

ORD record
ord-8c8c3e1d502b46fbbe9426a89420b007
Source dataset
uspto-grants-1991_05
Patent number
US05017596

Reaction notes

Loading…