HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 1-Methyl-α-[3-(trifluoromethyl)phenyl]-1H-imidazole-2-methanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Sodium borohydride | HCID 4311764 | — |
| Reactant | HCID 5303840 | HCID 5303840 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 1-Methyl-α-[3-(trifluoromethyl)phenyl]-1H-imidazole-2-methanol | HCID 11536187 | — |
Reaction Steps
0.6 g of sodium borohydride is added to a solution of 3.6 g of 1-methyl-α-(3-trifluoromethylphenyl) -1H-imidazole-2-methanone in 25 ml of methanol. The mixture is stirred for 30 minutes and 150 ml of water are added. The precipitate obtained is filtered off and washed with water. It is recrystallized from an ethanol/water mixture.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05017596 |
| Source dataset | uspto-grants-1991_05 |
| ORD ID | ord-8c8c3e1d502b46fbbe9426a89420b007 |
| Source note | uspto-grants-1991_05 |