Ethyl 2-chloro-3-nitro-beta-oxobenzenepropanoate → 1-(2-Chloro-3-nitrophenyl)ethanone

HRID 2051234Notes

Reaction equation

HRID 2051234 reaction equation
[Cl:1][C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][CH:5]=[CH:4][C:3]=1[C:11](=[O:18])[CH2:12]C(OCC)=O.O.FC(F)(F)C(O)=O>>[Cl:1][C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][CH:5]=[CH:4][C:3]=1[C:11](=[O:18])[CH3:12]

Participants

3

Reactant 2

HCID 15735718Ethyl 2-chloro-3-nitro-beta-oxobenzenepropanoateHCID 22392675Trifluoroacetic acid water

Product 1

HCID 124638851-(2-Chloro-3-nitrophenyl)ethanoneYield 87.6%

Procedure

According to the procedure of Example 2, ethyl 2-chloro-3-nitro-β-oxobenzenepropanoate (14.0 g, 51.5 mmol) is reacted with 30% water/trifluoroacetic acid to give 1-(2-chloro-3-nitrophenyl)ethanone (9.0 g, 87%), mp=41-43° C.

Sources & evidence

ORD record
ord-1146b14d05d44b9e9ff59fa053e043b5
Source dataset
uspto-grants-1991_05
Patent number
US05017604

Reaction notes

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