Hydrochloric Acid → HCID 14401240, compound
Reaction equation
[F:1][C:2](I)([F:7])[C:3]([F:6])([F:5])[F:4].[Cl:9][C:10]1[CH:18]=[CH:17][CH:16]=[CH:15][C:11]=1[C:12](Cl)=[O:13].Cl.O>C(Cl)Cl>[Cl:9][C:10]1[CH:18]=[CH:17][CH:16]=[CH:15][C:11]=1[C:12]([OH:13])([C:2]([F:7])([F:1])[C:3]([F:6])([F:5])[F:4])[C:2]([F:7])([F:1])[C:3]([F:6])([F:5])[F:4]Participants
Reactant 4
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 0 °C
Procedure
74 g (0.3 mol) of phosphorous acid trisdiethylamide in 150 ml of CH2Cl2 were initially introduced into a round-bottomed flask with the exclusion of moisture. 74 g (0.3 mol) of pentafluoroethyl iodide and 26.4 g (0.15 mol) of o-chlorobenzoyl chloride were added at about -20° C. The mixture was warmed to 0° C. and stirred for about 8 hours at this temperature. 10 g of hydrogen chloride gas were then introduced, and the mixture was stirred for a further hour at 0° C. The reaction mixture was freed from solvent under reduced pressure and introduced into 3 times the volume of water. The organic phase was separated off, dried and distilled. 34.6 g (62%) of 3-(2-chlorophenyl)-1,1,1,2,2,4,4,5,5,5-decafluoropentan-3-ol of b.p. 66° C./2 mbar were obtained.
Workup
- stirringthe mixture was stirred for a further hour at 0° C
- customThe organic phase was separated off
- customdried
- distillationdistilled
Sources & evidence
- ORD record
- ord-7ecb74a67b304fef91a68e97dbb61520
- Source dataset
- uspto-grants-1991_05
- Patent number
- US05017719
Reaction notes
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