HRID2051381

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID6328

Methyl iodide

CH3I

HCID14797

Potassium hydroxide

HKO

结构：CC(=O)Nc1ccc(Br)c2c1C(=O)c1ccccc1C2=O

HCID7730236

N-(4-Bromo-9,10-dioxo-9,10-dihydroanthracen-1-yl)acetamide

C16H10BrNO3

PRODUCTS

生成物

结构：CC(=O)N(C)c1ccc(Br)c2c1C(=O)c1ccccc1C2=O

HCID80770

Acetamide, N-(4-bromo-9,10-dihydro-9,10-dioxo-1-anthracenyl)-N-methyl-

C17H12BrNO3

收率 96.1%

AUXILIARIES

试剂、催化剂与溶剂

催化剂HCID74236

未命名化合物

溶剂HCID7964

Chlorobenzene

C6H5Cl

CONDITIONS

反应条件

温度: 30 °C

PROCEDURE

实验过程

A mixture of 4-bromo-1-acetylaminoanthraquinone (purity 98%, 35.1 g), monochlorobenzene (420 g), tetra-n-butyl ammonium bromide (0.3 g) and 96% potassium hydroxide (12.0 g) was stirred for 1 hour, while being maintained at 30° C. Then, methyl iodide (28.4 g) was dropped at 30° C. over 2 hours. The mixture was stirred at 30° C. for 30 minutes and 40° C. for 3 hours, successively. Then the same procedure as in Example 3 was applied to obtain 4-bromo-N-acetyl-1-methylaminoanthraquinone (35.1 g, purity 94.4%, yield 92.6%).

WORKUP

后处理

stirringThe mixture was stirred at 30° C. for 30 minutes and 40° C. for 3 hours