反应详情

285.2 Grams of cyclohexyl 3,5-dimethyl-2methoxyphenyl ketone was dissolved in 800 ml of acetic acid. To the solution was added 8 ml of 47% hydrobromic acid and then a solution prepared by dissolving 212 g of bromine in 100 ml of acetic acid was added thereto dropwise with ice-cooling and stirring. After stirring at room temperature for 2 hours, the reaction mixture was poured into ice water, followed by extraction with 2 liters of ethyl acetate. The extract was washed with water and then with a saturated aqueous sodium chloride solution and then dried with anhydrous magnesium sulfate and the solvent was distilled off under reduced pressure to obtain 363.6 g of 1-bromocyclohexyl 3,5-dimethyl-2-methoxyphenyl ketone.

1. customa solution prepared
2. additionwas added
3. temperaturedropwise with ice-cooling
4. stirringAfter stirring at room temperature for 2 hours
5. extractionfollowed by extraction with 2 liters of ethyl acetate
6. washThe extract was washed with water
7. dry with materialwith a saturated aqueous sodium chloride solution and then dried with anhydrous magnesium sulfate
8. distillationthe solvent was distilled off under reduced pressure