2-Amino-2-methyl-1-propanol → HCID 14988383, compound

Participants

Reaction Conditions

Reaction Steps

A solution of (R)-2-(tetrazolo[1,5-a]pyrid 6-yl)oxirane (0.25 g, 1.54 mmol) and 2-amino-2-methyl-1-propanol (0.275 g, 3.08 mmol) in 1 ml of absolute ethanol in a sealed reaction tube was heated at 120° C. (bath temperature) for two hours. The reaction mixture was concentrated under reduced pressure and then purified by preparative Tlc (silica gel; 80:20:0.5 methylene chloride:methanol: concentrated NH4OH) to afford 355 mg (92%) of product.

Provenance & Evidence