2-Amino-2-methyl-1-propanol → HCID 14988383, compound

HRID 2051489Notes

Reaction equation

HRID 2051489 reaction equation
[N:1]1[N:2]=[N:3][N:4]2[CH:9]=[C:8]([C@@H:10]3[CH2:12][O:11]3)[CH:7]=[CH:6][C:5]=12.[NH2:13][C:14]([CH3:18])([CH3:17])[CH2:15][OH:16]>C(O)C>[CH3:17][C:14]([NH:13][CH2:12][C@@H:10]([C:8]1[CH:7]=[CH:6][C:5]2[N:4]([N:3]=[N:2][N:1]=2)[CH:9]=1)[OH:11])([CH3:18])[CH2:15][OH:16]

Participants

4

Reactant 2

HCID 118072-Amino-2-methyl-1-propanolHCID 13090314(R)-2-(tetrazolo[1,5-a]pyrid 6-yl)oxirane

Product 1

HCID 14988383HCID 14988383, compoundYield 92%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
120 °C

Procedure

A solution of (R)-2-(tetrazolo[1,5-a]pyrid 6-yl)oxirane (0.25 g, 1.54 mmol) and 2-amino-2-methyl-1-propanol (0.275 g, 3.08 mmol) in 1 ml of absolute ethanol in a sealed reaction tube was heated at 120° C. (bath temperature) for two hours. The reaction mixture was concentrated under reduced pressure and then purified by preparative Tlc (silica gel; 80:20:0.5 methylene chloride:methanol: concentrated NH4OH) to afford 355 mg (92%) of product.

Workup

  1. concentrationThe reaction mixture was concentrated under reduced pressure
  2. custompurified by preparative Tlc (silica gel; 80:20:0.5 methylene chloride:methanol: concentrated NH4OH)

Sources & evidence

ORD record
ord-f8846da97fa741bc822b2f128f2ccdb4
Source dataset
uspto-grants-1991_05
Patent number
US05019578

Reaction notes

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