2-Butanamine, 2-methyl- → HCID 14988385, compound

HRID 2051490Notes

Reaction equation

HRID 2051490 reaction equation
[N:1]1[N:2]=[N:3][N:4]2[CH:9]=[C:8]([C@@H:10]3[CH2:12][O:11]3)[CH:7]=[CH:6][C:5]=12.[C:13]([NH2:18])([CH2:16][CH3:17])([CH3:15])[CH3:14]>C(O)C>[CH3:14][C:13]([NH:18][CH2:12][C@@H:10]([C:8]1[CH:7]=[CH:6][C:5]2[N:4]([N:3]=[N:2][N:1]=2)[CH:9]=1)[OH:11])([CH3:15])[CH2:16][CH3:17]

Participants

4

Reactant 2

HCID 689862-Butanamine, 2-methyl-HCID 13090314(R)-2-(tetrazolo[1,5-a]pyrid 6-yl)oxirane

Product 1

HCID 14988385HCID 14988385, compoundYield 96.1%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 250 mg (1.54 mmol) of (R)-2-(tetrazolo[1,5-a]pyrid-6-yl)oxirane and 663 mg (7.61 mmol) of tert amylamine in 0.6 ml of absolute ethanol in a pressure tube was heated at 100° C. (bath temperature) for two hours. The reaction mixture was concentrated under reduced pressure to yield 369 mg of crude product which was used in the next reaction without further purification.

Workup

  1. concentrationThe reaction mixture was concentrated under reduced pressure

Sources & evidence

ORD record
ord-f350358f24e349459a71230262238378
Source dataset
uspto-grants-1991_05
Patent number
US05019578

Reaction notes

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