反应详情

The hydrochloride (0.1 mole) obtained in Example 1 is dissolved in methanol (400 ml). Sodium methoxide (0.22 mole) in methanol solution is added thereto. The material is cooled to 0°-5° C. and potassium borohydride (0.4 mole) is added thereto. The material is stirred overnight. It is then evaporated in vacuo without heating, taken up into ether/H2O. The ethereal phase is washed with water, dried and evaporated, to give a pale yellow oil which is converted to the hydrochloride by addition of ethereal hydrochloric acid. M.p.=220° C.

1. temperatureThe material is cooled to 0°-5° C.
2. customIt is then evaporated in vacuo
3. temperaturewithout heating
4. washThe ethereal phase is washed with water
5. customdried
6. customevaporated
7. customto give a pale yellow oil which