HCID 178498869, compound → HCID 178420608, compound

HRID 2051707Notes

Reaction equation

HRID 2051707 reaction equation
[CH:1]([N:14]1[C:18]([C:19]([O:21]C)=[O:20])=[CH:17][N:16]=[C:15]1[SH:23])([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>N1CCCC1>[NH:16]1[CH2:15][CH2:19][CH2:18][CH2:17]1.[CH:1]([N:14]1[C:18]([C:19]([OH:21])=[O:20])=[CH:17][N:16]=[C:15]1[SH:23])([C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1)[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1

Participants

3

Reactant 1

HCID 178498869HCID 178498869, compound

Product 1

HCID 178420608HCID 178420608, compound

Reagents, catalysts & solvents 1

HCID 31268PyrrolidineSolvent

Procedure

In a nitrogen atmosphere 3.2 g (0.01 mol) of 1-benzhydryl-2-mercapto-5-methoxycarbonyl-imidazole (Example 1a) and 60 cc of pyrrolidine were refluxed for 3 days. Excess pyrrolidine was then removed in vacuo and the 1-benzhydryl-2-mercapto-5-imidazole-carboxylic acid pyrrolidine obtained was recrystallized from methanol (m.p. 263° C.). The yield was 3.3 g (91% of the theory).

Workup

  1. customExcess pyrrolidine was then removed in vacuo

Sources & evidence

ORD record
ord-8c44001f5d1749aebe1d71c4248da29e
Source dataset
uspto-grants-1980_01
Patent number
US04182624

Reaction notes

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