Chloral → HCID 20378050, compound

HRID 2051749Notes

Reaction equation

HRID 2051749 reaction equation
O1CC(C([O-])=O)OC1C([O-])=O.[Na+].[Na+].[O:14]=[CH:15][C:16]([Cl:19])([Cl:18])[Cl:17].Br[CH:21]([CH2:26][OH:27])[C:22]([O:24][CH3:25])=[O:23].C(=O)([O-])[O-].[K+].[K+]>CCCCCC>[CH3:25][O:24][C:22]([CH:21]1[CH2:26][O:27][CH:15]([C:16]([Cl:19])([Cl:18])[Cl:17])[O:14]1)=[O:23]

Participants

6

Reactant 4

HCID 6407ChloralHCID 11430Potassium Carbonate2×HCID 11964350methyl 2-bromo-3-hydroxypropionateHCID 20378063HCID 20378063, compound

Product 1

HCID 20378050HCID 20378050, compound

Reagents, catalysts & solvents 1

HCID 8058HexaneSolvent

Procedure

This compound was prepared as a possible alternate precursor to the title compound of Example 5 (c). Chloral 15.1 g (0.102 mol) and 22 g of methyl 2-bromo-3-hydroxypropionate, as prepared in Example 5(a) were mixed, and after returning to room temperature the mixture was treated with hexane 50 ml and 14.1 g (0.102 mol) potassium carbonate (added in portions over 0.5 hour). After stirring for 6 hours an additional 5 g of potassium carbonate was added and the mixture allowed to stir overnight.

Workup

  1. additionwere mixed
  2. customafter returning to room temperature
  3. additionwas added

Sources & evidence

ORD record
ord-8e4851fe484442aaa7ad7cee20b48ee0
Source dataset
uspto-grants-1980_01
Patent number
US04182718

Reaction notes

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