Water → 2-[(2-pyridylmethyl)thio]-1H-naphth[2,3-d]imidazole

HRID 2051768Notes

Reaction equation

HRID 2051768 reaction equation
[CH3:1][S:2][C:3]1[NH:7][C:6]2[CH:8]=[C:9]3[C:14](=[CH:15][C:5]=2[N:4]=1)[CH:13]=[CH:12][CH:11]=[CH:10]3.SC[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][N:19]=1.O>C(O)C>[N:19]1[CH:20]=[CH:21][CH:22]=[CH:23][C:18]=1[CH2:1][S:2][C:3]1[NH:4][C:5]2[CH:15]=[C:14]3[C:9](=[CH:8][C:6]=2[N:7]=1)[CH:10]=[CH:11][CH:12]=[CH:13]3

Participants

5

Reactant 3

HCID 962WaterHCID 2560712-PyridinemethanethiolHCID 128720792-(methylthio)-1H-naphtho[2,3-d]imidazole

Product 1

HCID 223941842-[(2-pyridylmethyl)thio]-1H-naphth[2,3-d]imidazoleYield 81.7%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

0.45 g of 2-methylthio-1H-naphth[2,3-d]imidazole and 0.64 g of 2-mercaptomethylpyridine were heated for 40 hours under reflux in 10 ml of ethanol. 10 ml of water were added to the homogeneous solution and the precipitate formed was filtered off. 0.50 g of 2-[(2-pyridylmethyl)thio]-1H-naphth[2,3-d]imidazole having a m.p. of 170° was obtained.

Workup

  1. customthe precipitate formed
  2. filtrationwas filtered off

Sources & evidence

ORD record
ord-8cffeb46b0b14b5395d8e0e24fdbc492
Source dataset
uspto-grants-1980_01
Patent number
US04182766

Reaction notes

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