Isopropylamine → HCID 54461745, compound

HRID 2051798Notes

Reaction equation

O=[CH:2][C@@H:3]([C@H:5]([C@@H:7]([C@@H:9]([CH2:11][OH:12])[OH:10])[OH:8])[OH:6])[OH:4].[CH:13]([NH2:16])([CH3:15])[CH3:14].[Cl:17][CH2:18][CH2:19][N:20]=[C:21]=[O:22]>>[Cl:17][CH2:18][CH2:19][NH:20][C:21]([N:16]([CH:13]([CH3:15])[CH3:14])[CH:2]1[O:10][C@H:9]([CH2:11][OH:12])[C@@H:7]([OH:8])[C@H:5]([OH:6])[C@H:3]1[OH:4])=[O:22]

Participants

Reactant 3

HCID 6363Isopropylamine

HCID 160352-Chloroethyl isocyanate

HCID 107526(2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanal

Product 1

HCID 54461745HCID 54461745, compoundYield 73.5%

Procedure

3.6 g of D-glucose, 2.0 g of isopropylamine and 2.5 g of 2-chloroethyl isocyanate are treated in the same manner as described in Example 5-(1). 4.8 g of 1-(2-chloroethyl)-3-isopropyl-3-D-glucopyranosylurea are obtained as colorless caramel.

Sources & evidence

ORD record: ord-f1fcd7d409fa4b40b886daa34d030eab
Source dataset: uspto-grants-1980_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04182757

Reaction notes

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