Sodium Nitrite → HCID 13092710, compound

HRID 2051801Notes

Reaction equation

HRID 2051801 reaction equation
[Cl:1][CH2:2][CH2:3][NH:4][C:5]([N:7]([CH2:19][CH2:20][CH2:21][CH3:22])[CH:8]1[O:16][C@H:15]([CH2:17][OH:18])[C@@H:13]([OH:14])[C@H:11]([OH:12])[C@H:9]1[OH:10])=[O:6].[N:23]([O-])=[O:24].[Na+]>C(O)=O>[Cl:1][CH2:2][CH2:3][N:4]([N:23]=[O:24])[C:5]([N:7]([CH2:19][CH2:20][CH2:21][CH3:22])[CH:8]1[O:16][C@H:15]([CH2:17][OH:18])[C@@H:13]([OH:14])[C@H:11]([OH:12])[C@H:9]1[OH:10])=[O:6]

Participants

4

Reactant 2

HCID 23668193Sodium NitriteHCID 53937511HCID 53937511, compound

Product 1

HCID 13092710HCID 13092710, compound

Reagents, catalysts & solvents 1

HCID 284Formic AcidSolvent

Procedure

2.2 g of 1-(2-chloroethyl)-3-n-butyl-3-D-glucopyranosylurea are dissolved in 10 ml of formic acid, and one g of sodium nitrite is added gradually thereto at 0° to 5° C. for 40 minutes under stirring. The mixture is further stirred at the same temperature for 1.5 hours. After the reaction, the mixture is treated in the same manner as described in Example 5-(2). 1.0 g of 1-(2-chloroethyl)-1-nitroso-3-n-butyl-3-D-glucopyranosylurea is thereby obtained as pale yellow caramel.

Workup

  1. stirringThe mixture is further stirred at the same temperature for 1.5 hours
  2. customAfter the reaction
  3. additionthe mixture is treated in the same manner

Sources & evidence

ORD record
ord-59f7f6b37a2f46c19552939322802a5c
Source dataset
uspto-grants-1980_01
Patent number
US04182757

Reaction notes

Loading…