Sodium Nitrite → HCID 13092710, compound

Participants

Reaction Steps

2.2 g of 1-(2-chloroethyl)-3-n-butyl-3-D-glucopyranosylurea are dissolved in 10 ml of formic acid, and one g of sodium nitrite is added gradually thereto at 0° to 5° C. for 40 minutes under stirring. The mixture is further stirred at the same temperature for 1.5 hours. After the reaction, the mixture is treated in the same manner as described in Example 5-(2). 1.0 g of 1-(2-chloroethyl)-1-nitroso-3-n-butyl-3-D-glucopyranosylurea is thereby obtained as pale yellow caramel.

Provenance & Evidence