HCID 20378131, compound → HCID 20378118, compound

HRID 2051855Notes

Reaction equation

HRID 2051855 reaction equation
[Cl:1][CH2:2][CH2:3][NH:4][C:5]([N:7]([CH2:11][CH2:12][OH:13])[CH2:8][CH2:9][OH:10])=[O:6].[N:14]([O-])=[O:15].[Na+].C(Cl)(Cl)Cl.CO>C(O)(=O)C>[Cl:1][CH2:2][CH2:3][N:4]([N:14]=[O:15])[C:5]([N:7]([CH2:11][CH2:12][OH:13])[CH2:8][CH2:9][OH:10])=[O:6]

Participants

5

Reactant 3

HCID 20378131HCID 20378131, compoundHCID 21584188Chloroform methanolHCID 23668193Sodium Nitrite

Product 1

HCID 20378118HCID 20378118, compoundYield 65.9%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

4.0 g of 1-(2-chloroethyl)-3,3-bis(2-hydroxyethyl)urea are dissolved in 30 ml of acetic acid, and 2.5 g of sodium nitrite are added thereto under stirring. The mixture is stirred at room temperature for 4 hours. After the reaction, the mixture is treated in the same manner as described in Example 60-(2) (Solvent used for chromatography: chloroform-methanol (10:1)). 3.0 g of 1-(2-chloroethyl)-1-nitroso-3,3-bis(2-hydroxyethyl)urea are thereby obtained as a yellow oil.

Workup

  1. stirringThe mixture is stirred at room temperature for 4 hours
  2. customAfter the reaction
  3. additionthe mixture is treated in the same manner

Sources & evidence

ORD record
ord-3f7482764c654de8b97224ba02263918
Source dataset
uspto-grants-1980_01
Patent number
US04182757

Reaction notes

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