HCID 20378131, compound → HCID 20378118, compound

Participants

Reaction Steps

4.0 g of 1-(2-chloroethyl)-3,3-bis(2-hydroxyethyl)urea are dissolved in 30 ml of acetic acid, and 2.5 g of sodium nitrite are added thereto under stirring. The mixture is stirred at room temperature for 4 hours. After the reaction, the mixture is treated in the same manner as described in Example 60-(2) (Solvent used for chromatography: chloroform-methanol (10:1)). 3.0 g of 1-(2-chloroethyl)-1-nitroso-3,3-bis(2-hydroxyethyl)urea are thereby obtained as a yellow oil.

Provenance & Evidence