Sodium Hydroxide → HCID 70591936, compound

HRID 2051883Notes

Reaction equation

HRID 2051883 reaction equation
[NH2:1][C:2]1[C:7]([C:8](=[O:16])[C:9]2[CH:14]=[CH:13][C:12]([F:15])=[CH:11][CH:10]=2)=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:17][C:18]([OH:20])=[O:19].[OH-].[Na+:22]>O1CCCC1>[OH2:16].[NH2:1][C:2]1[C:7]([C:8](=[O:16])[C:9]2[CH:14]=[CH:13][C:12]([F:15])=[CH:11][CH:10]=2)=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:17][C:18]([O-:20])=[O:19].[Na+:22]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 12901229HCID 12901229, compound

Product 1

HCID 70591936HCID 70591936, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A solution of 1 g. (0.0036 mole) of 2-amino-3-(4-fluorobenzoyl)phenylacetic acid in 10 ml. of tetrahydrofuran was treated with 0.7 g. of a 50% sodium hydroxide solution (0.009 mole) and stirred under nitrogen for 15 min. before a yellow precipitate developed. The stirred mixture was cooled in an ice bath for 2 hr. The precipitate was then filtered off and air-dried. Recrystallization from tetrahydrofuran-water yielded 150 mg. (20%) of product which melted at 240°-250° C. (dec.).

Workup

  1. temperatureThe stirred mixture was cooled in an ice bath for 2 hr
  2. filtrationThe precipitate was then filtered off
  3. customair-dried
  4. customRecrystallization from tetrahydrofuran-water
  5. customyielded 150 mg

Sources & evidence

ORD record
ord-44b3497cca9e41418e4af0a99b5b08e2
Source dataset
uspto-grants-1980_01
Patent number
US04182774

Reaction notes

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