Triethylamine → HCID 23468302, compound

HRID 2051888Notes

Reaction equation

HRID 2051888 reaction equation
[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[O:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][OH:18].C(N(CC)CC)C.[CH3:26][S:27](Cl)(=[O:29])=[O:28]>ClCCl>[CH3:26][S:27]([O:18][CH2:17][CH2:16][CH2:15][CH2:14][CH2:13][CH2:12][O:11][C:2]1[CH:3]=[CH:4][C:5]2[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=2)[CH:1]=1)(=[O:29])=[O:28]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 14856822HCID 14856822, compound

Product 1

HCID 23468302HCID 23468302, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a mixture of 10.4 g. of 6-(2-naphthyloxy)-1-hexanol and 8.1 g. of triethylamine in 250 ml. of dichloromethane chilled to -8° C. under nitrogen is added dropwise 5.1 g of methanesulfonyl chloride. After one hour at 0° to -8° C., the mixture is washed with cold water, 10% hydrochloric acid solution, saturated sodium bicarbonate solution, saturated sodium chloride solution, and dried (magnesium sulfate). The solvent is removed under vacuum to give the product as a white solid.

Workup

  1. additionTo a mixture of 10.4 g
  2. washthe mixture is washed with cold water, 10% hydrochloric acid solution, saturated sodium bicarbonate solution, saturated sodium chloride solution
  3. dry with materialdried (magnesium sulfate)
  4. customThe solvent is removed under vacuum

Sources & evidence

ORD record
ord-540f5f66ac184f2dae44fa8d1469df29
Source dataset
uspto-grants-1980_01
Patent number
US04182776

Reaction notes

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