HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzocaine → Ethyl p-{[2-(2-naphthyloxy)ethyl]amino}benzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzocaine | HCID 2337 | — |
| Reactant | 2-(2-Naphthyloxy)ethyl methanesulfonate | HCID 19004383 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Hexamethylphosphoramide | HCID 12679 | — |
| Product | Ethyl p-{[2-(2-naphthyloxy)ethyl]amino}benzoate | HCID 23468273 | — |
Reaction Steps
A mixture of 18.7 g of 2-(2-naphthyloxy)ethanol O-methanesulfonate and 23.6 g of ethyl p-aminobenzoate is heated in 300 ml of hexamethylphosphoramide at 110° C. for 16 hours. The mixture is cooled, diluted with water, and worked up as described in Example 3 to give the crystalline product. Recrystallization from ethanol gives crystals, mp 158°-162° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04182776 |
| Source dataset | uspto-grants-1980_01 |
| ORD ID | ord-7a35e72c7c9645f0a2a0c2e5ec65b1a4 |
| Source note | uspto-grants-1980_01 |