Benzocaine → HCID 23468280, compound

HRID 2051897Notes

Reaction equation

HRID 2051897 reaction equation
CS(O[CH2:6][CH2:7][O:8][C:9]1[C:18]2[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=2)[CH:12]=[CH:11][CH:10]=1)(=O)=O.[NH2:19][C:20]1[CH:30]=[CH:29][C:23]([C:24]([O:26][CH2:27][CH3:28])=[O:25])=[CH:22][CH:21]=1>CN(C)P(N(C)C)(N(C)C)=O>[C:9]1([O:8][CH2:7][CH2:6][NH:19][C:20]2[CH:21]=[CH:22][C:23]([C:24]([O:26][CH2:27][CH3:28])=[O:25])=[CH:29][CH:30]=2)[C:18]2[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=2)[CH:12]=[CH:11][CH:10]=1

Participants

4

Reactant 2

HCID 2337BenzocaineHCID 23468298HCID 23468298, compound

Product 1

HCID 23468280HCID 23468280, compound

Reagents, catalysts & solvents 1

HCID 12679HexamethylphosphoramideSolvent

Procedure

A solution of 29.1 g of 2-(1-naphthyloxy)ethanol O-methanesulfonate and 33 g of ethyl p-aminobenzoate in 100 ml of hexamethylphosphoramide is heated at 100° C. for 16 hours. The solution is worked up as described in Example 3 to give the product. Recrystallization gives crystals, mp 124°-127° C.

Workup

  1. customto give the product
  2. customRecrystallization
  3. customgives crystals, mp 124°-127° C.

Sources & evidence

ORD record
ord-0886274feb0e457ba442d8956a70d872
Source dataset
uspto-grants-1980_01
Patent number
US04182776

Reaction notes

Loading…