反应详情

A solution of 22.8 g of β-bromo-2,4-dichlorophenetole and 29.8 g of ethyl 4-aminobenzoate in 100 ml of hexamethylphosphoramide is heated at 125° C. for 16 hours. The solution is chilled, diluted with water (80 ml) and filtered. The solid is washed with 50% ethanol to give the product. Recrystallization from ethanol gives crystals, mp 111°-113° C.

1. temperatureThe solution is chilled
2. filtrationfiltered
3. washThe solid is washed with 50% ethanol
4. customto give the product
5. customRecrystallization from ethanol
6. customgives crystals, mp 111°-113° C.