HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzocaine → Ethyl p-{[2-(2,4-dichlorophenoxy)ethyl]amino}benzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzocaine | HCID 2337 | — |
| Reactant | 1-(2-Bromoethoxy)-2,4-dichlorobenzene | HCID 138881 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Hexamethylphosphoramide | HCID 12679 | — |
| Product | Ethyl p-{[2-(2,4-dichlorophenoxy)ethyl]amino}benzoate | HCID 20378376 | — |
Reaction Steps
A solution of 22.8 g of β-bromo-2,4-dichlorophenetole and 29.8 g of ethyl 4-aminobenzoate in 100 ml of hexamethylphosphoramide is heated at 125° C. for 16 hours. The solution is chilled, diluted with water (80 ml) and filtered. The solid is washed with 50% ethanol to give the product. Recrystallization from ethanol gives crystals, mp 111°-113° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04182776 |
| Source dataset | uspto-grants-1980_01 |
| ORD ID | ord-d571a8a72637411d8ba99361549051b7 |
| Source note | uspto-grants-1980_01 |