Benzocaine → HCID 20378380, compound

HRID 2051903Notes

Reaction equation

HRID 2051903 reaction equation
CS(O[CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][O:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)(=O)=O.[NH2:19][C:20]1[CH:30]=[CH:29][C:23]([C:24]([O:26][CH2:27][CH3:28])=[O:25])=[CH:22][CH:21]=1>CN(C)P(N(C)C)(N(C)C)=O>[O:12]([CH2:11][CH2:10][CH2:9][CH2:8][CH2:7][CH2:6][NH:19][C:20]1[CH:21]=[CH:22][C:23]([C:24]([O:26][CH2:27][CH3:28])=[O:25])=[CH:29][CH:30]=1)[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1

Participants

4

Reactant 2

HCID 2337BenzocaineHCID 20378398HCID 20378398, compound

Product 1

HCID 20378380HCID 20378380, compound

Reagents, catalysts & solvents 1

HCID 12679HexamethylphosphoramideSolvent

Procedure

A solution of 13.6 g of 6-(phenoxy)-1-hexanol O-methanesulfonate and 16.5 g of ethyl p-aminobenzoate in 75 ml of hexamethylphosphoramide is heated at 110° C. for 16 hours. The product is isolated as described in Example 3 to give crystals. Recrystallization from ethanol gives crystals, mp 105°-108° C.

Workup

  1. customThe product is isolated
  2. customto give crystals
  3. customRecrystallization from ethanol
  4. customgives crystals, mp 105°-108° C.

Sources & evidence

ORD record
ord-af58c6b97b374320950b1c9ab218e388
Source dataset
uspto-grants-1980_01
Patent number
US04182776

Reaction notes

Loading…