Hydrochloric Acid → HCID 20378393, compound

HRID 2051910Notes

Reaction equation

HRID 2051910 reaction equation
[O:1]([CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][NH:19][C:20]1[CH:30]=[CH:29][C:23]([C:24]([O:26]CC)=[O:25])=[CH:22][CH:21]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-].[K+].C(O)C.O.Cl>O>[O:1]([CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][NH:19][C:20]1[CH:30]=[CH:29][C:23]([C:24]([OH:26])=[O:25])=[CH:22][CH:21]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 19096565Water ethanolHCID 20378382HCID 20378382, compound

Product 1

HCID 20378393HCID 20378393, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of 7.0 g of ethyl p-[(11-phenoxyundecyl)amino]benzoate, 7.0 g of potassium hydroxide and 150 ml of ethanol-water (9:1) is refluxed for 3.5 hours. The mixture is made acidic while hot with concentrated hydrochloric acid, diluted with water, cooled and filtered to give white crystals, mp 117°-119° C. Recrystallization from ethanol gives white crystals, mp 118°-119.5° C.

Workup

  1. temperatureis refluxed for 3.5 hours
  2. temperaturecooled
  3. filtrationfiltered
  4. customto give white crystals, mp 117°-119° C
  5. customRecrystallization from ethanol
  6. customgives white crystals, mp 118°-119.5° C.

Sources & evidence

ORD record
ord-5ca2356d3ba04f58b9adda44bc1cf25a
Source dataset
uspto-grants-1980_01
Patent number
US04182776

Reaction notes

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