Hydrochloric Acid → HCID 20378379, compound

HRID 2051912Notes

Reaction equation

HRID 2051912 reaction equation
[O:1]([CH2:8][CH2:9][NH:10][C:11]1[CH:21]=[CH:20][C:14]([C:15]([O:17]CC)=[O:16])=[CH:13][CH:12]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-].[K+].C(O)C.O.Cl>O>[O:1]([CH2:8][CH2:9][NH:10][C:11]1[CH:12]=[CH:13][C:14]([C:15]([OH:17])=[O:16])=[CH:20][CH:21]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 19096565Water ethanolHCID 20378381HCID 20378381, compound

Product 1

HCID 20378379HCID 20378379, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of 12 g of ethyl p-(2-phenoxyethylamino)-benzoate, 12 g of potassium hydroxide and 200 ml of ethanol-water (9:1) is refluxed for 3.5 hours. The solution is acidified while hot with concentrated hydrochloric acid, diluted with water, cooled, filtered and the solid washed with water to give crystals, mp 172°-175° C. Recrystallization from ethanol gives off-white crystals, mp 174°-176° C.

Workup

  1. temperatureis refluxed for 3.5 hours
  2. temperaturecooled
  3. filtrationfiltered
  4. washthe solid washed with water
  5. customto give crystals, mp 172°-175° C
  6. customRecrystallization from ethanol
  7. customgives off-white crystals, mp 174°-176° C.

Sources & evidence

ORD record
ord-5192135bd74e4fca96d3478a4c4a3610
Source dataset
uspto-grants-1980_01
Patent number
US04182776

Reaction notes

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