Hydrochloric Acid → HCID 20378378, compound

HRID 2051914Notes

Reaction equation

HRID 2051914 reaction equation
[O:1]([CH2:8][CH2:9][CH2:10][NH:11][C:12]1[CH:22]=[CH:21][C:15]([C:16]([O:18]CC)=[O:17])=[CH:14][CH:13]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-].[K+].C(O)C.O.Cl>O>[O:1]([CH2:8][CH2:9][CH2:10][NH:11][C:12]1[CH:13]=[CH:14][C:15]([C:16]([OH:18])=[O:17])=[CH:21][CH:22]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 19096565Water ethanolHCID 20378391HCID 20378391, compound

Product 1

HCID 20378378HCID 20378378, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of 15 g of ethyl p-[(3-phenoxypropyl)-amino]benzoate, 15 g of potassium hydroxide and 150 ml of ethanol-water (9:1) is refluxed for 3.5 hours. The mixture is acidified while hot with concentrated hydrochloric acid, diluted with water, chilled and filtered to give yellow crystals, mp 159°-162° C. Recrystallization from ethanol gives pale yellow crystals, mp 161°-163° C.

Workup

  1. temperatureis refluxed for 3.5 hours
  2. temperaturechilled
  3. filtrationfiltered
  4. customto give yellow crystals, mp 159°-162° C
  5. customRecrystallization from ethanol
  6. customgives pale yellow crystals, mp 161°-163° C.

Sources & evidence

ORD record
ord-77c55e0d6209462f9b88820193f4eca9
Source dataset
uspto-grants-1980_01
Patent number
US04182776

Reaction notes

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