反应详情

A mixture of 3.0 g of ethyl p-{[2-(2-naphthyloxy)-ethyl]amino}benzoate, and 3.0 g of potassium hydroxide in 200 ml of ethanol-water (95:5) is refluxed for 3 hours. The mixture is diluted with 100 ml of water and brought to pH 6.0 with concentrated hydrochloric acid. The mixture is filtered and the solid washed with 50 ml of water and 20 ml of cold ethanol-water (4:1) to give the product, mp 208°-211° C.

1. temperatureis refluxed for 3 hours
2. filtrationThe mixture is filtered
3. washthe solid washed with 50 ml of water and 20 ml of cold ethanol-water (4:1)
4. customto give the product, mp 208°-211° C.