反应详情

A mixture of 4.5 g. of ethyl 4-{[3-(4-chlorophenoxy)propyl]amino}benzoate 4.5 g. of potassium hydroxide and 100 ml. of 95% ethanol is refluxed for 3 hours. The solution is acidified with hydrochloric acid and the mixture is diluted with 100 ml. of water to give 3.7 g. of solid. Recrystallization by dissolving in a mixture of chloroform-ethyl acetate and diluting with hexane gives 3.3 g. of product as off-white crystals, m.p. 180°-181° C.

1. additionA mixture of 4.5 g
2. additionthe mixture is diluted with 100 ml
3. customRecrystallization
4. dissolutionby dissolving in a mixture of chloroform-ethyl acetate
5. additiondiluting with hexane
6. customgives 3.3 g