反应详情

A solution of 3.0 g (0.013 mole) of N-(1-methylimidazol-2-yl)-N'-phenylthiourea in 50 ml of methanol is added 2.13 g (0.015 mole) of methyl iodide. The solution is heated under reflux for 2 hr, the solvent is evaporated and the residue is recrystallized from acetone-ether to give methyl N-(1-methylimidazol-2-yl)-N'-phenylcarbamimidothioate hydroiodide; m.p. 115°-118° C.

1. temperatureThe solution is heated
2. temperatureunder reflux for 2 hr
3. customthe solvent is evaporated
4. customthe residue is recrystallized from acetone-ether