Methyl iodide → HCID 178503857, compound

HRID 2052067Notes

Reaction equation

HRID 2052067 reaction equation
[CH3:1][N:2]1[CH:6]=[CH:5][N:4]=[C:3]1[NH:7][C:8]([NH:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)=[S:9].[CH3:17][I:18]>CO>[IH:18].[CH3:1][N:2]1[CH:6]=[CH:5][N:4]=[C:3]1[NH:7][C:8]([S:9][CH3:17])=[N:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1

Participants

4

Reactant 2

HCID 6328Methyl iodideHCID 20378498N-(1-methylimidazol-2-yl)-N'-phenylthiourea

Product 1

HCID 178503857HCID 178503857, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of 3.0 g (0.013 mole) of N-(1-methylimidazol-2-yl)-N'-phenylthiourea in 50 ml of methanol is added 2.13 g (0.015 mole) of methyl iodide. The solution is heated under reflux for 2 hr, the solvent is evaporated and the residue is recrystallized from acetone-ether to give methyl N-(1-methylimidazol-2-yl)-N'-phenylcarbamimidothioate hydroiodide; m.p. 115°-118° C.

Workup

  1. temperatureThe solution is heated
  2. temperatureunder reflux for 2 hr
  3. customthe solvent is evaporated
  4. customthe residue is recrystallized from acetone-ether

Sources & evidence

ORD record
ord-400c710788dd4492a1beb4781e19078d
Source dataset
uspto-grants-1980_01
Patent number
US04182865

Reaction notes

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