反应详情

The reference compound IV in the HPLC analysis was prepared as follows: 1 g (1.8 mmol) of t-butyl 2-bromo-3-bromomethyl-7-phenylacetamido-3-cephem-4-carboxylate 1-oxide [prepared by the procedure of Step C of Example II] was dissolved in 15 ml of trifluoroacetic acid and after standing for 15 minutes at room temperature, the solution was evaporated to dryness. The residue was dissolved in methylene chloride and the solution was again evaporated to dryness. The residue was treated with diethyl ether and the product was isolated by filtration and was washed with diethyl ether and hexane to obtain 0.8 g (88% yield) of 2-bromo-3-bromomethyl-7-phenylacetamido-3-cephem-4-carboxylic acid 1-oxide.

1. customthe solution was evaporated to dryness
2. dissolutionThe residue was dissolved in methylene chloride
3. customthe solution was again evaporated to dryness
4. additionThe residue was treated with diethyl ether
5. customthe product was isolated by filtration
6. washwas washed with diethyl ether and hexane