Formic Acid → HCID 14115790, compound

HRID 2052124Notes

Reaction equation

HRID 2052124 reaction equation
[F:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([NH2:8])=[O:7])=[CH:4][CH:3]=1.[P:11]([Cl:16])(Cl)(Cl)(Cl)[Cl:12].Cl.C(O)=[O:19]>C(Cl)(Cl)(Cl)Cl>[Cl:12][P:11]([Cl:16])([NH:8][C:6](=[O:7])[C:5]1[CH:9]=[CH:10][C:2]([F:1])=[CH:3][CH:4]=1)=[O:19]

Participants

6

Reactant 4

HCID 284Formic AcidHCID 313Hydrochloric AcidHCID 24819Phosphorus pentachlorideHCID 715724-Fluorobenzamide

Product 1

HCID 14115790HCID 14115790, compound

Reagents, catalysts & solvents 1

HCID 5943Carbon TetrachlorideSolvent

Procedure

A mixture of 19.5 g (0.14 mole) of 4-fluorobenzamide, 29.2 g (0.14 mole) of phosphorus pentachloride and 175 ml of carbon tetrachloride was heated at 60°-70° for 30 min. or until the HCl gas evolution had nearly stopped. The reaction was cooled to 25°-30° and 6.7 g (0.14 mole) of 97% formic acid was added dropwise. Stirring was continued for another 60 min. before the precipitate was collected by filtration, washed with AR carbon tetrachloride and air-dried to give 20.4 g, m.p. softens 109°, melts 110°-112°.

Workup

  1. temperatureThe reaction was cooled to 25°-30°
  2. filtrationwas collected by filtration
  3. washwashed with AR carbon tetrachloride
  4. customair-dried
  5. customto give 20.4 g
  6. customm.p. softens 109°
  7. custommelts 110°-112°

Sources & evidence

ORD record
ord-15cb1306b98b4858add89120cbd82a42
Source dataset
uspto-grants-1980_01
Patent number
US04182881

Reaction notes

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