Formic Acid → HCID 20378781, compound

HRID 2052126Notes

Reaction equation

HRID 2052126 reaction equation
[Cl:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([NH2:8])=[O:7])=[CH:4][CH:3]=1.[P:11]([Cl:16])(Cl)(Cl)(Cl)[Cl:12].C(O)=[O:18].Cl>C(Cl)(Cl)(Cl)Cl>[Cl:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([NH:8][P:11]([Cl:16])([Cl:12])=[O:18])=[O:7])=[CH:4][CH:3]=1

Participants

6

Reactant 4

HCID 284Formic AcidHCID 313Hydrochloric AcidHCID 120844-ChlorobenzamideHCID 24819Phosphorus pentachloride

Product 1

HCID 20378781HCID 20378781, compound

Reagents, catalysts & solvents 1

HCID 5943Carbon TetrachlorideSolvent

Procedure

A suspension of 68 g, (0.44 mole) of 4-chlorobenzamide, 91 g (0.44 mole) of phosphorus pentachloride and 700 ml of AR carbon tetrachloride was heated at 65°-70° for 25 min. The solution was cooled to 20° and 20.7 g (0.44 mole) of 97% formic acid added dropwise. After the HCl gas evolution had nearly stopped, ca. 30 min., the precipitate was collected by filtration, washed with AR carbon tetrachloride and air-dried to give 103 g, m.p. 114.5°-115.5°.

Workup

  1. temperaturewas heated at 65°-70° for 25 min
  2. temperatureThe solution was cooled to 20°
  3. filtrationthe precipitate was collected by filtration
  4. washwashed with AR carbon tetrachloride
  5. customair-dried
  6. customto give 103 g, m.p. 114.5°-115.5°

Sources & evidence

ORD record
ord-cfb53d91cff346fd94b51387b9fa8d1a
Source dataset
uspto-grants-1980_01
Patent number
US04182881

Reaction notes

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