Formic Acid → HCID 20378765, compound

HRID 2052127Notes

Reaction equation

HRID 2052127 reaction equation
[CH3:1][O:2][C:3]1[CH:11]=[CH:10][C:6]([C:7]([NH2:9])=[O:8])=[CH:5][CH:4]=1.[P:12]([Cl:17])(Cl)(Cl)(Cl)[Cl:13].Cl.C(O)=[O:20]>C(Cl)(Cl)(Cl)Cl>[Cl:13][P:12]([Cl:17])([NH:9][C:7](=[O:8])[C:6]1[CH:10]=[CH:11][C:3]([O:2][CH3:1])=[CH:4][CH:5]=1)=[O:20]

Participants

6

Reactant 4

HCID 284Formic AcidHCID 313Hydrochloric AcidHCID 24819Phosphorus pentachlorideHCID 769594-Methoxybenzamide

Product 1

HCID 20378765HCID 20378765, compound

Reagents, catalysts & solvents 1

HCID 5943Carbon TetrachlorideSolvent

Procedure

A suspension of 47 g (0.31 mole) of 4-methoxybenzamide, 64.7 g (0.31 mole) of phosphorus pentachloride and 500 ml of AR carbon tetrachloride was heated at 60°-70° for 45 min. by which time the HCl evolution had nearly stopped. Cooled to room temperature where 14.8 g (0.31 mole) of 97% formic acid was added dropwise. The reaction was stirred for an additional 30 min., then filtered, washed with AR carbon tetrachloride and air-dried to give 73.4 g, m.p. 92°-93°.

Workup

  1. additionwas added dropwise
  2. filtrationfiltered
  3. washwashed with AR carbon tetrachloride
  4. customair-dried
  5. customto give 73.4 g, m.p. 92°-93°

Sources & evidence

ORD record
ord-ece99c1debff42c6bc95dee590ce0ba4
Source dataset
uspto-grants-1980_01
Patent number
US04182881

Reaction notes

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