Formic Acid → HCID 20378782, compound

HRID 2052131Notes

Reaction equation

HRID 2052131 reaction equation
[F:1][C:2]([F:13])([F:12])[C:3]1[CH:4]=[C:5]([CH:9]=[CH:10][CH:11]=1)[C:6]([NH2:8])=[O:7].[P:14]([Cl:19])(Cl)(Cl)(Cl)[Cl:15].Cl.C(O)=[O:22]>C(Cl)(Cl)(Cl)Cl>[Cl:15][P:14]([Cl:19])([NH:8][C:6](=[O:7])[C:5]1[CH:9]=[CH:10][CH:11]=[C:3]([C:2]([F:12])([F:13])[F:1])[CH:4]=1)=[O:22]

Participants

6

Reactant 4

HCID 284Formic AcidHCID 313Hydrochloric AcidHCID 24819Phosphorus pentachlorideHCID 74535m-(Trifluoromethyl)benzamide

Product 1

HCID 20378782HCID 20378782, compound

Reagents, catalysts & solvents 1

HCID 5943Carbon TetrachlorideSolvent

Procedure

A suspension of 15 g (0.08 mole) of 3-trifluoromethylbenzamide, 16.5 g (0.08 mole) of phosphorus pentachloride and 150 ml of AR carbon tetrachloride was heated at 65°-70° until the HCl gas evolution nearly stops, ca. 30 min. The solution was cooled to 30° and 3.8 g (0.08 mole) of 97% formic acid added dropwise. Stirring was continued for 30 min., then the precipitate was collected, washed with AR carbon tetrachloride and air-dried to give 14 g, m.p. softens 112°, melts 114°-116°.

Workup

  1. temperatureThe solution was cooled to 30°
  2. waitwas continued for 30 min.
  3. customthe precipitate was collected
  4. washwashed with AR carbon tetrachloride
  5. customair-dried
  6. customto give 14 g
  7. customm.p. softens 112°
  8. custommelts 114°-116°

Sources & evidence

ORD record
ord-14b7e017b51f48d288a735ff9d910874
Source dataset
uspto-grants-1980_01
Patent number
US04182881

Reaction notes

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