Formic Acid → HCID 20378774, compound

HRID 2052134Notes

Reaction equation

HRID 2052134 reaction equation
[C:1]1([CH2:7][C:8]([NH2:10])=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[P:11]([Cl:16])(Cl)(Cl)(Cl)[Cl:12].Cl.C(O)=[O:19]>C(Cl)(Cl)(Cl)Cl>[Cl:12][P:11]([Cl:16])([NH:10][C:8](=[O:9])[CH2:7][C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1)=[O:19]

Participants

6

Reactant 4

HCID 284Formic AcidHCID 313Hydrochloric AcidHCID 7680BenzeneacetamideHCID 24819Phosphorus pentachloride

Product 1

HCID 20378774HCID 20378774, compound

Reagents, catalysts & solvents 1

HCID 5943Carbon TetrachlorideSolvent

Procedure

A suspension of 50 g (0.37 mole) of phenylacetamide, 77 g (0.37 mole) of phosphorus pentachloride and 500 ml of AR carbon tetrachloride was heated at 70° for 25 min. or until the HCl gas evolution ceases. The resulting solution was cooled to 30°, then 17.6 g (0.37 mole) of 97% formic acid was added, dropwise. Stirred at 30° for 30 min. following the addition, then filtered, washed with AR carbon tetrachloride and air-dried to give 80 g, m.p. softens 79°, some melts 83°-94°, complete 120°.

Workup

  1. temperatureThe resulting solution was cooled to 30°
  2. additionthe addition
  3. filtrationfiltered
  4. washwashed with AR carbon tetrachloride
  5. customair-dried
  6. customto give 80 g
  7. customm.p. softens 79°
  8. customsome melts 83°-94°, complete 120°

Sources & evidence

ORD record
ord-41b5dffa248345dc8d56091a4355df19
Source dataset
uspto-grants-1980_01
Patent number
US04182881

Reaction notes

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