Ammonia → 4-Phenylbenzamide

HRID 2052144Notes

Reaction equation

HRID 2052144 reaction equation
[C:1]1([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[CH:6]=[CH:5][C:4]([C:7](Cl)=[O:8])=[CH:3][CH:2]=1.[NH3:16]>C(Cl)(Cl)Cl>[C:10]1([C:1]2[CH:6]=[CH:5][C:4]([C:7]([NH2:16])=[O:8])=[CH:3][CH:2]=2)[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 841514-Phenylbenzoyl chloride

Product 1

HCID 6025064-Phenylbenzamide

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

A mixture of 27 g (0.12 mole) of 4-biphenylcarbonyl chloride and 300 ml of AR chloroform was saturated with anhydrous ammonia while maintaining a temperature of 20°. Following the 20 min. addition the white precipitate was collected, washed with cold water and oven-dried (60°) to give 23.5 g, m.p. shrinks 228°, melts 230°-233°.

Workup

  1. temperaturewhile maintaining a temperature of 20°
  2. additionthe 20 min. addition the white precipitate
  3. customwas collected
  4. washwashed with cold water
  5. customoven-dried (60°)
  6. customto give 23.5 g
  7. customshrinks 228°
  8. custommelts 230°-233°

Sources & evidence

ORD record
ord-1e78e7e665dc42208b0c1debf78051be
Source dataset
uspto-grants-1980_01
Patent number
US04182881

Reaction notes

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