Ammonia → 2,4-Dimethylbenzamide

HRID 2052146Notes

Reaction equation

HRID 2052146 reaction equation
[NH3:1].[CH3:2][C:3]1[CH:11]=[C:10]([CH3:12])[CH:9]=[CH:8][C:4]=1[C:5](Cl)=[O:6]>C(Cl)(Cl)Cl>[CH3:2][C:3]1[CH:11]=[C:10]([CH3:12])[CH:9]=[CH:8][C:4]=1[C:5]([NH2:1])=[O:6]

Participants

4

Reactant 2

HCID 222AmmoniaHCID 1408672,4-Dimethylbenzoyl chloride

Product 1

HCID 128623922,4-Dimethylbenzamide

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

Saturated with anhydrous ammonia, a solution of 50 g (0.3 mole) of 2,4-dimethylbenzoyl chloride and 500 ml of AR chloroform, while maintaining a temperature of 15°. Stirred for 20 min., then filtered, washed with cold distilled water and oven-dried at 60° to give 29.1 g, m.p. 184°-186°.

Workup

  1. filtrationfiltered
  2. washwashed
  3. distillationwith cold distilled water
  4. customoven-dried at 60°
  5. customto give 29.1 g, m.p. 184°-186°

Sources & evidence

ORD record
ord-95271637ff844c6bb7b4599e8eba72f1
Source dataset
uspto-grants-1980_01
Patent number
US04182881

Reaction notes

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