1,1'-(Diazomethylene)bis(benzene) → HCID 14525271, compound

HRID 2052173Notes

Reaction equation

HRID 2052173 reaction equation
[CH:1]([C:3]1[CH2:4][S:5][C@@H:6]2[CH:13](NC(=O)CC3SC=CC=3)[C:12](=[O:23])[N:7]2[C:8]=1[C:9]([OH:11])=[O:10])=[O:2].[C:24]1([C:30]([C:33]2[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=2)=[N+]=[N-])[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1>O1CCCC1>[CH:30]([O:11][C:9]([C:8]1[N:7]2[C:12](=[O:23])[CH2:13][C@H:6]2[S:5][CH2:4][C:3]=1[CH:1]=[O:2])=[O:10])([C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1)[C:33]1[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=1

Participants

4

Reactant 2

HCID 612301,1'-(Diazomethylene)bis(benzene)HCID 88776188HCID 88776188, compound

Product 1

HCID 14525271HCID 14525271, compoundYield 130%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To a stirred solution of 3.5 g of 3-formyl-7-thienylacetamido-3-cephem-4-carboxylic acid in 100 ml of tetrahydrofuran is added 2.3 g of diphenyldiazomethane, and the stirring is continued for 30 min. The solvent is distilled off under reduced pressure, and the residue is washed with petroleum ether to give 4.9 g of the corresponding 3-formyl-3-cephem-4-carboxylic acid benzhydryl ester.

Workup

  1. distillationThe solvent is distilled off under reduced pressure
  2. washthe residue is washed with petroleum ether

Sources & evidence

ORD record
ord-093f2b5b4ccc4281a000c5b07968bcfc
Source dataset
uspto-grants-1980_01
Patent number
US04182866

Reaction notes

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