反应详情

1-Aminopyridinium chloride (7.9g) was added to potassium hydroxide (6.72g) in water (60 ml). 4-Cyanopyridine (31.2g) was added to ethanol (63 ml). The two solutions were then admixed at room temperature and left for 66 hours. The ethanol was then evaporated off in vacuo, and the residue extracted with chloroform (100 ml). The chloroform extract was dried over magnesium sulphate, filtered, and evaporated in vacuo. Recrystallisation of the product from ethanol gave 2-(4-pyridyl)-s-triazolo[1,5-a]pyridine (6.3g), mp 188°-190° C.

1. customwere then admixed at room temperature
2. customThe ethanol was then evaporated off in vacuo
3. extractionthe residue extracted with chloroform (100 ml)
4. extractionThe chloroform extract
5. dry with materialwas dried over magnesium sulphate
6. filtrationfiltered
7. customevaporated in vacuo
8. customRecrystallisation of the product from ethanol