Water → HCID 20377205, compound

HRID 2052224Notes

Reaction equation

HRID 2052224 reaction equation
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]([C:8]1[CH:16]=[CH:15][CH:14]=[C:13]2[C:9]=1[CH2:10][CH2:11][CH:12]2[C:17]#[N:18])=[O:7].[OH2:19]>>[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]([C:8]1[CH:16]=[CH:15][CH:14]=[C:13]2[C:9]=1[CH2:10][CH2:11][CH:12]2[C:17]([NH2:18])=[O:19])=[O:7]

Participants

3

Reactant 2

HCID 962WaterHCID 12439126HCID 12439126, compound

Product 1

HCID 20377205HCID 20377205, compound

Conditions

Temperature
80 °C

Procedure

To 2.5 g of 4-(2-thienylcarbonyl)-1-indancarbonitrile is added 50 g of polyphosphoric acid and, with occasional stirring, the mixture is heated at 80° C. for 2.5 hours. The polyphosphoric acid is decomposed by the addition of water, followed by extraction with ethyl acetate. The extract is washed with water and dried. The solvent is distilled off under reduced pressure and the residue obtained is recrystallized from ethyl acetate. By the above procedure is obtained 4-(2-thienylcarbonyl)-1-indancarboxamide as crystals melting at 164°-166° C.

Workup

  1. extractionfollowed by extraction with ethyl acetate
  2. washThe extract is washed with water
  3. customdried
  4. distillationThe solvent is distilled off under reduced pressure
  5. customthe residue obtained
  6. customis recrystallized from ethyl acetate

Sources & evidence

ORD record
ord-28d6c6e766d140a3a326d0e5a0bd8374
Source dataset
uspto-grants-1980_01
Patent number
US04183859

Reaction notes

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