Water → HCID 20377205, compound

Participants

Reaction Conditions

Reaction Steps

To 2.5 g of 4-(2-thienylcarbonyl)-1-indancarbonitrile is added 50 g of polyphosphoric acid and, with occasional stirring, the mixture is heated at 80° C. for 2.5 hours. The polyphosphoric acid is decomposed by the addition of water, followed by extraction with ethyl acetate. The extract is washed with water and dried. The solvent is distilled off under reduced pressure and the residue obtained is recrystallized from ethyl acetate. By the above procedure is obtained 4-(2-thienylcarbonyl)-1-indancarboxamide as crystals melting at 164°-166° C.

Provenance & Evidence