Methyl isothiocyanate → HCID 20377482, compound

HRID 2052247Notes

Reaction equation

HRID 2052247 reaction equation
[CH3:1][N:2]=[C:3]=[S:4].[CH2:5]([O:7][C:8]([CH2:10][O:11][CH2:12][C:13]([NH:15][NH2:16])=[O:14])=[O:9])[CH3:6]>O1CCCC1>[CH3:1][NH:2][C:3]([NH:16][NH:15][C:13]([CH2:12][O:11][CH2:10][C:8]([O:7][CH2:5][CH3:6])=[O:9])=[O:14])=[S:4]

Participants

4

Reactant 2

HCID 11167Methyl isothiocyanateHCID 20377449HCID 20377449, compound

Product 1

HCID 20377482HCID 20377482, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A solution of methyl isothiocyanate (3.52 g.) in dry tetrahydrofuran (20 ml.) was added during the course of 30 minutes to a suspension of ethoxycarbonylmethoxyacetohydrazide (8.50 g.) in absolute alcohol (50 ml.), and the resulting mixture was stirred for a further period of two hours. The solution was then filtered and the clear filtrate evaporated in vacuo. Trituration of the residue with dry diethyl ether then gave the compound CH3NHCSNHNHCOCH2OCH2COOEt as a white solid material (yield, 8.0 g.).

Workup

  1. filtrationThe solution was then filtered
  2. customthe clear filtrate evaporated in vacuo
  3. customTrituration of the residue with dry diethyl ether then gave

Sources & evidence

ORD record
ord-11b331af05d44dc38455ac71e970ec51
Source dataset
uspto-grants-1980_01
Patent number
US04183925

Reaction notes

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