HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2052255Generated: October 30, 2026
Methanethiol → 17alpha-Methylthio-1,4-Androstadiene-3,11-Dione
https://huagongshe.com/reaction/2052255
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methanethiol | HCID 878 | — |
| Reactant | Sodium | HCID 5360545 | — |
| Reactant | 17beta-Methanesulfonyloxy-1,4-androstadiene-3,11-dione | HCID 56609103 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 17alpha-Methylthio-1,4-Androstadiene-3,11-Dione | HCID 54358159 | — |
Reaction Steps
To 6.9 gm. of sodium metal dissolved in 225 ml. of ethanol is added 30 ml. of methylmercaptan followed by 10 gm. of 17β-methanesulfonyloxy-1,4-androstadiene-3,11-dione. Heat at reflux for 18 hours. Cool the solution to 0° C., filter solids and crystallize from chloroform/hexane to obtain the title compound; m.p. 180°-183° C.; [α]D26 +101.6° (DMF).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04183924 |
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| Source dataset | uspto-grants-1980_01 |
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| ORD ID | ord-4d72ea8ffee140d8805e2f915f730ea0 |
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| Source note | uspto-grants-1980_01 |
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